6-hydroxynicotinate dehydrogenase

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In enzymology, a 6-hydroxynicotinate dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

6-hydroxynicotinate + H2O + O2 2,6-dihydroxynicotinate + H2O2

The 3 substrates of this enzyme are 6-hydroxynicotinate, H2O, and O2, whereas its two products are 2,6-dihydroxynicotinate and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 group with oxygen as acceptor. The systematic name of this enzyme class is 6-hydroxynicotinate:O2 oxidoreductase. Other names in common use include 6-hydroxynicotinic acid hydroxylase, 6-hydroxynicotinic acid dehydrogenase, and 6-hydroxynicotinate hydroxylase.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Nagel M and Andreesen JR (1989). "Molybdenum-dependent degradation of nicotinic acid by Bacillus sp DSM 2923". FEMS Microbiol. Lett. 59: 147&ndash, 152.
  • Nagel M and Andreesen JR (1990). "Purification and characterization of the molybdoenzymes nicotinate dehydrogenase and 6-hydroxynicotinate dehydrogenase from Bacillus niacini". Arch. Microbiol. 154: 605&ndash, 613.

External links

Gene Ontology (GO) codes