4-hydroxyphenylacetaldehyde dehydrogenase

Jump to: navigation, search

In enzymology, a 4-hydroxyphenylacetaldehyde dehydrogenase (EC 1.2.1.53) is an enzyme that catalyzes the chemical reaction

4-hydroxyphenylacetaldehyde + NAD+ + H2O 4-hydroxyphenylacetate + NADH + 2 H+

The 3 substrates of this enzyme are 4-hydroxyphenylacetaldehyde, NAD+, and H2O, whereas its 3 products are 4-hydroxyphenylacetate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase. This enzyme is also called 4-HPAL dehydrogenase. This enzyme participates in tyrosine metabolism.

References

  • IUBMB entry for 1.2.1.53
  • BRENDA references for 1.2.1.53 (Recommended.)
  • PubMed references for 1.2.1.53
  • PubMed Central references for 1.2.1.53
  • Google Scholar references for 1.2.1.53
  • Cuskey SM, Peccoraro V, Olsen RH (1987). "Initial catabolism of aromatic biogenic amines by Pseudomonas aeruginosa PAO: pathway description, mapping of mutations, and cloning of essential genes". J. Bacteriol. 169: 2398&ndash, 404. PMID 3034855.

External links

The CAS registry number for this enzyme class is 109456-56-6.

Gene Ontology (GO) codes

Template:1.2-enzyme-stub


Linked-in.jpg