4-hydroxyphenylacetaldehyde dehydrogenase

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In enzymology, a 4-hydroxyphenylacetaldehyde dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

4-hydroxyphenylacetaldehyde + NAD+ + H2O 4-hydroxyphenylacetate + NADH + 2 H+

The 3 substrates of this enzyme are 4-hydroxyphenylacetaldehyde, NAD+, and H2O, whereas its 3 products are 4-hydroxyphenylacetate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase. This enzyme is also called 4-HPAL dehydrogenase. This enzyme participates in tyrosine metabolism.


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  • Cuskey SM, Peccoraro V, Olsen RH (1987). "Initial catabolism of aromatic biogenic amines by Pseudomonas aeruginosa PAO: pathway description, mapping of mutations, and cloning of essential genes". J. Bacteriol. 169: 2398&ndash, 404. PMID 3034855.

External links

The CAS registry number for this enzyme class is 109456-56-6.

Gene Ontology (GO) codes