2-hydroxypyridine 5-monooxygenase

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In enzymology, a 2-hydroxypyridine 5-monooxygenase (EC is an enzyme that catalyzes the chemical reaction

2-hydroxypyridine + AH2 + O2 2,5-dihydroxypyridine + A + H2O

The 3 substrates of this enzyme are 2-hydroxypyridine, AH2, and O2, whereas its 3 products are 2,5-dihydroxypyridine, A, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is 2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating). This enzyme is also called 2-hydroxypyridine oxygenase.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Sharma ML, Kaul SM and Shukla OP (1984). "Metabolism of 2-hydroxypyridine by Bacillus brevis (INA)". Biol. Membr. 9: 43&ndash, 52.

External links

The CAS registry number for this enzyme class is 96779-45-2.

Gene Ontology (GO) codes