2-hydroxycyclohexanone 2-monooxygenase

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In enzymology, a 2-hydroxycyclohexanone 2-monooxygenase (EC is an enzyme that catalyzes the chemical reaction

2-hydroxycyclohexan-1-one + NADPH + H+ + O2 Failed to parse (MathML with SVG or PNG fallback (recommended for modern browsers and accessibility tools): Invalid response ("Math extension cannot connect to Restbase.") from server "https://en.wikipedia.org/api/rest_v1/":): \rightleftharpoons 6-hydroxyhexan-6-olide + NADP+ + H2O

The 4 substrates of this enzyme are 2-hydroxycyclohexan-1-one, NADPH, H+, and O2, whereas its 3 products are 6-hydroxyhexan-6-olide, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is 2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing).


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Davey JF, Trudgill PW (1977). "The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species". Eur. J. Biochem. 74: 115&ndash, 27. PMID 856571.

External links

The CAS registry number for this enzyme class is 62628-31-3.

Gene Ontology (GO) codes