2-ethylmalate synthase

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In enzymology, a 2-ethylmalate synthase (EC is an enzyme that catalyzes the chemical reaction

acetyl-CoA + H2O + 2-oxobutanoate (R)-2-ethylmalate + CoA

The 3 substrates of this enzyme are acetyl-CoA, H2O, and 2-oxobutanoate, whereas its two products are (R)-2-ethylmalate and CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming). Other names in common use include (R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating), 2-ethylmalate-3-hydroxybutanedioate synthase, propylmalate synthase, and propylmalic synthase. This enzyme participates in pyruvate metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Strassman M, Ceci LN (1967). "A study of acetyl-CoA condensation with alpha-keto acids". Arch. Biochem. Biophys. 119: 420&ndash, 8. PMID 6052435.

External links

The CAS registry number for this enzyme class is 9024-01-5.

Gene Ontology (GO) codes