(carboxyethyl)arginine beta-lactam-synthase

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In enzymology, a (carboxyethyl)arginine beta-lactam-synthase (EC 6.3.3.4) is an enzyme that catalyzes the chemical reaction

ATP + L-N2-(2-carboxyethyl)arginine AMP + diphosphate + deoxyamidinoproclavaminate

Thus, the two substrates of this enzyme are ATP and L-N2-(2-carboxyethyl)arginine, whereas its 3 products are AMP, diphosphate, and deoxyamidinoproclavaminate.

This enzyme belongs to the family of ligases, specifically the cyclo-ligases, which form carbon-nitrogen bonds. The systematic name of this enzyme class is L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme is also called L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme participates in clavulanic acid biosynthesis.

References

  • IUBMB entry for 6.3.3.4
  • BRENDA references for 6.3.3.4 (Recommended.)
  • PubMed references for 6.3.3.4
  • PubMed Central references for 6.3.3.4
  • Google Scholar references for 6.3.3.4
  • Zhou J, Kelly WL, Bachmann BO, Gunsior M, Townsend CA, Solomon EI (2001). "Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities". J. Am. Chem. Soc. 123: 7388&ndash, 98. PMID 11472170.
  • Townsend CA (2002). "New reactions in clavulanic acid biosynthesis". Curr. Opin. Chem. Biol. 6: 583&ndash, 9. PMID 12413541.
  • Bachmann BO, Li R, Townsend CA (1998). "beta-Lactam synthetase: a new biosynthetic enzyme". Proc. Natl. Acad. Sci. U. S. A. 95: 9082&ndash, 6. PMID 9689037.

External links

Template:Ligase-stub



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