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		<id>https://www.wikidoc.org/index.php?title=Zestoretic_side_effects&amp;diff=602424</id>
		<title>Zestoretic side effects</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Zestoretic_side_effects&amp;diff=602424"/>
		<updated>2011-09-26T21:13:17Z</updated>

		<summary type="html">&lt;p&gt;Satzamanne1977: /* Anaphylactoid and Possibly Related Reactions */&lt;/p&gt;
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&lt;div&gt;{{CMG}}&lt;br /&gt;
==List of side effects==&lt;br /&gt;
&amp;lt;font size=&amp;quot;4&amp;quot;&amp;gt;[[Zestoretic side effects#Anaphylactoid and Possibly Related Reactions|Anaphylactoid and Possibly Related Reactions]]&amp;lt;/font&amp;gt;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;font size=&amp;quot;4&amp;quot;&amp;gt;[[Zestoretic side effects#Head and Neck Angioedema|Head and Neck Angioedema]]&amp;lt;/font&amp;gt;&lt;br /&gt;
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&amp;lt;font size=&amp;quot;4&amp;quot;&amp;gt;[[Zestoretic side effects#Intestinal Angioedema|Intestinal Angioedema]]&amp;lt;/font&amp;gt;&lt;br /&gt;
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&amp;lt;font size=&amp;quot;4&amp;quot;&amp;gt;[[Zestoretic side effects#Anaphylactoid Reactions During Desensitization|Anaphylactoid Reactions During Desensitization]]&amp;lt;/font&amp;gt;&lt;br /&gt;
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&amp;lt;font size=&amp;quot;4&amp;quot;&amp;gt;[[Zestoretic side effects#Anaphylactoid Reactions During Membrane Exposure|Anaphylactoid Reactions During Membrane Exposure]]&amp;lt;/font&amp;gt;&lt;br /&gt;
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&amp;lt;br&amp;gt;&lt;br /&gt;
&amp;lt;font size=&amp;quot;4&amp;quot;&amp;gt;[[Zestoretic side effects#Hypotension and Related Effects|Hypotension and Related Effects]]&amp;lt;/font&amp;gt;&lt;br /&gt;
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&amp;lt;font size=&amp;quot;4&amp;quot;&amp;gt;[[Zestoretic side effects#Hepatic Failure|Hepatic Failure]]&amp;lt;/font&amp;gt;&lt;br /&gt;
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&amp;lt;font size=&amp;quot;4&amp;quot;&amp;gt;[[Zestoretic side effects#Pregnancy|Pregnancy]]&amp;lt;/font&amp;gt;&lt;br /&gt;
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===Head and Neck Angioedema===&lt;br /&gt;
Angioedema of the face, extremities, lips, tongue, glottis and/or larynx has been&lt;br /&gt;
reported rarely in patients treated with angiotensin-converting&lt;br /&gt;
enzyme inhibitors, including lisinopril. This may occur at any&lt;br /&gt;
time during treatment. ACE inhibitors have been associated&lt;br /&gt;
with a higher rate of angioedema in black than in nonblack&lt;br /&gt;
patients. ZESTORETIC should be promptly discontinued and&lt;br /&gt;
the appropriate therapy and monitoring should be provided&lt;br /&gt;
until complete and sustained resolution of signs and symptoms&lt;br /&gt;
has occurred. Where there is involvement of the&lt;br /&gt;
tongue, glottis or larynx, likely to cause airway&lt;br /&gt;
obstruction, subcutaneous epinephrine solution 1:1000 (0.3&lt;br /&gt;
mL to 0.5 mL) and/or measures necessary to ensure a&lt;br /&gt;
patent airway should be promptly provided. &#039;&#039;[[Zestoretic side effects#List of side effects|Return to top]]&#039;&#039;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
===Intestinal Angioedema===&lt;br /&gt;
Intestinal angioedema has been&lt;br /&gt;
reported in patients treated with ACE inhibitors. These&lt;br /&gt;
patients presented with abdominal pain (with or without&lt;br /&gt;
nausea or vomiting); in some cases there was no prior history&lt;br /&gt;
of facial angioedema and C-1 esterase levels were normal.&lt;br /&gt;
The angioedema was diagnosed by procedures including&lt;br /&gt;
abdominal CT scan or ultrasound, or at surgery, and&lt;br /&gt;
symptoms resolved after stopping the ACE inhibitor.&lt;br /&gt;
Intestinal angioedema should be included in the differential&lt;br /&gt;
diagnosis of patients on ACE inhibitors presenting with&lt;br /&gt;
abdominal pain. &#039;&#039;[[Zestoretic side effects#List of side effects|Return to top]]&#039;&#039;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
===Anaphylactoid Reactions During Desensitization===&lt;br /&gt;
Two patients undergoing desensitizing treatment with hymenoptera&lt;br /&gt;
venom while receiving ACE inhibitors sustained life&lt;br /&gt;
threatening anaphylactoid reactions. In the same patients,&lt;br /&gt;
these reactions were avoided when ACE inhibitors were&lt;br /&gt;
temporarily withheld, but they reappeared upon inadvertent&lt;br /&gt;
rechallenge. &#039;&#039;[[Zestoretic side effects#List of side effects|Return to top]]&#039;&#039;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
===Anaphylactoid Reactions During Membrane Exposure===&lt;br /&gt;
Thiazide-containing combination products are not&lt;br /&gt;
recommended in patients with severe renal dysfunction.&lt;br /&gt;
Sudden and potentially life-threatening anaphylactoid&lt;br /&gt;
reactions have been reported in some patients dialyzed with&lt;br /&gt;
high-flux membranes (eg, AN69®*) and treated concomitantly&lt;br /&gt;
with an ACE inhibitor. In such patients, dialysis must be&lt;br /&gt;
stopped immediately, and aggressive therapy for&lt;br /&gt;
anaphylactoid reactions be initiated. Symptoms have not been&lt;br /&gt;
relieved by antihistamines in these situations. In these&lt;br /&gt;
patients, consideration should be given to using a different&lt;br /&gt;
type of dialysis membrane or a different class of&lt;br /&gt;
antihypertensive agent. &#039;&#039;[[Zestoretic side effects#List of side effects|Return to top]]&#039;&#039;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
===Hypotension and Related Effects===&lt;br /&gt;
Excessive hypotension was rarely seen in uncomplicated hypertensive patients but is&lt;br /&gt;
a possible consequence of lisinopril use in&lt;br /&gt;
salt/volume-depleted persons such as those treated vigorously&lt;br /&gt;
with diuretics or patients on dialysis. &#039;&#039;[[Zestoretic side effects#List of side effects|Return to top]]&#039;&#039;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
===Hepatic Failure===&lt;br /&gt;
Rarely, ACE inhibitors have been&lt;br /&gt;
associated with a syndrome that starts with cholestatic&lt;br /&gt;
jaundice or hepatitis and progresses to fulminant hepatic&lt;br /&gt;
necrosis and (sometimes) death. The mechanism of this&lt;br /&gt;
syndrome is not understood. Patients receiving ACE&lt;br /&gt;
inhibitors who develop jaundice or marked elevations of&lt;br /&gt;
hepatic enzymes should discontinue the ACE inhibitor and&lt;br /&gt;
receive appropriate medical follow-up. &#039;&#039;[[Zestoretic side effects#List of side effects|Return to top]]&#039;&#039;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
===Pregnancy===&lt;br /&gt;
When used in pregnancy during the second and third&lt;br /&gt;
trimesters, ACE inhibitors can cause injury and even death to&lt;br /&gt;
the developing fetus. When pregnancy is detected,&lt;br /&gt;
ZESTORETIC should be discontinued as soon as possible. &#039;&#039;[[Zestoretic side effects#List of side effects|Return to top]]&#039;&#039;&lt;br /&gt;
&amp;lt;br&amp;gt;&lt;br /&gt;
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{{FDA}}&lt;/div&gt;</summary>
		<author><name>Satzamanne1977</name></author>
	</entry>
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